Mental and body health concept. Calm and smiling adult african american sporty woman sitting in meditation on yoga mat, making sport exercise at home, training in living room.

You take your hemp supplements every day, and maybe you’ve noticed less pain, better sleep, or an uplifted sense of wellbeing. But have you ever asked yourself, “How does CBD work?” Often extracted from the hemp variety of the cannabis plant, CBD is an information-relaying compound known as a cannabinoid. Because of the unique chemical makeup of cannabinoids, they mimic your body’s naturally-occurring endocannabinoids. By doing this, they are able to provide you with an individualized health experience to enhance your wellness routine. 

The good news is that, unlike tetrahydrocannabinol (THC), CBD is not psychoactive. This means you won’t experience a “high” when taking it. In fact, CBD has been shown to help reduce the high that some people experience when using THC, which is helpful for those who are taking cannabis to help manage a medical condition.

To better understand just how CBD helps elevate your health, let’s take a look at your body’s own self-regulating “oversight” system, which was first discovered in the early 1990’s.

How Does CBD Work?

The Endocannabinoid System (ECS)

While researching how cannabis compounds affect humans, scientists were surprised to discover a whole new system in our bodies. They called it the Endocannabinoid System (ECS) after the cannabis compounds that they were studying.

The ECS is made up of 3 main parts:

  • At least two key endocannabinoids (neurotransmitters) called anandamide and 2-AG
  • Endocannabinoid receptors called CB1 (mainly in the brain) and CB2 (mainly in the body)
  • Enzymes to properly break down these endocannabinoids

What was discovered about the ECS is that its endocannabinoids work with CB1 and CB2 receptors to positively regulate and maintain many of our most important bodily processes, including metabolic, immune, digestive, mental, and nervous system functions. Even more exciting was the discovery that cannabis cannabinoids such as CBD work in much the same way as these health-boosting endocannabinoids. This means they can “step in” to take their place when needed. 

Why is this so important? To answer this question, let’s take a look at what happens when your ECS breaks down.

A sketch of a human's endocannabinoid system featuring various receptors in the body, answering the question "How does CBD work?"

Understanding Endocannabinoid Deficiency

Just like every system in your body, the ECS can become deficient in key elements needed to function optimally. Since the ECS oversees so many processes in the body, the effects of these deficiencies can have a huge negative impact on your health. 

In fact, the ECS is so important to our overall health and wellbeing that its depletion is considered a medical condition. Called Clinical Endocannabinoid Deficiency (CED), it arises when your body doesn’t produce enough endocannabinoids and receptors to properly send out the chemical signals needed to keep your body’s systems running smoothly. This can be due to improper nutrition, a high-stress lifestyle, medical conditions, and environmental factors.

CED has been shown to be an underlying cause of many medical conditions, such as:

  • Lowered Immunity
  • Migraines
  • Depression
  • Digestive Issues
  • Fibromyalgia
  • Anxiety
  • Inflammation
  • Chronic Pain

A Powerful Healthcare Team: CBD and Your Endocannabinoid System

CBD has been shown to replenish and balance your ECS, in large part through its ability to reduce the uptake and breakdown of anandamide, one of your body’s key endocannabinoids. The word anandamide actually means ‘bliss’ in Sanskrit, and this name is attributed to this natural chemical’s many positive health benefits, including:

  • Regulating mood
  • Reducing inflammation
  • Managing pain levels
  • Regulating appetite
  • Inhibiting certain types of cancer cell production

The bonus? CBD is considered safe and effective with little to no side effects. That’s why many medical professionals have recommended it to supplement or replace pharmaceuticals in certain cases of chemotherapy-induced nausea and chronic pain management. It’s even been approved by the Federal Drug Administration (FDA) in the first pharmaceutical-grade CBD medication, which is used to treat two types of childhood epilepsy. Just like with any medicinal treatment, you should check with your doctor before taking CBD, especially if you are using other medications, or are pregnant or breastfeeding.

Take a look at how CBD works to relieve symptoms in some of the most common health conditions.

trupura CBD bath salts on a marble slab, laid out with cotton balls, a bath towel, and a tropical plant.


Did you know that chronic inflammation is now considered a key underlying cause of many leading health conditions, including heart disease, cancer, diabetes, nerve conditions, and chronic pain? CBD’s anti-inflammatory properties are well documented. It has been shown to be a sort of ‘checks and balances’ therapy to help prevent healthy inflammation from becoming chronic and debilitating. For example, while it doesn’t bind directly to CB1 or CB2 receptors, it does bind to receptors known as TPRV1 in order to properly modulate inflammation.

Today, scientists are even studying CBD as a promising treatment for the severe lung inflammation that’s associated with advanced cases of Covid-19 because it comes with far fewer side effects than other anti-inflammatory medications that have been tested. 


Nearly 20% of adults in the United States had some form of anxiety disorder in the past year, and almost a third will experience the condition at some point in their lifetime.

CBD works in a few crucial ways to help you better manage anxiety, including by enhancing signaling between CB1 receptors and anandamide in key areas of your brain responsible for emotional regulation. Some research also reveals that CBD positively interacts with serotonin receptors to help lower your heart rate and blood pressure.

Pain Relief

Many people are looking for natural remedies that help soothe the aches and pains associated with exercise, injuries, and chronic medical conditions. In addition to its work at relieving the inflammation that can cause nerve pain in conditions such as arthritis, CBD acts on the central nervous system by activating 5-HT1a receptors. This in turn triggers the release of the “happy” hormone serotonin to help reduce your pain perception levels.

CBD’s ability to bind to TPRV1 receptors also makes it a sought after therapy for pain relief. In fact, in a recent study of over 2,700 people, nearly half said they substituted cannabis (that contains the CBD compound) for their prescription pain, anxiety, and depression drugs. CBD’s popularity as a pain reliever may stem from its wide variety of pain management pathways that can make it an effective treatment even in difficult cases.

Experience the trupura CBD Difference

Our handcrafted line of top-tier, medical-focused CBD products have been created using our team’s combined experience with patient advocacy, natural remedies, and nutritional foods. Contact us today to learn more about how trupura CBD’s trustworthy, triple lab-tested hemp oils, salves, chocolates, bath salts, gummies, tinctures, and creams can help you balance back to an optimal state of health.

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