You’re probably familiar with THC and CBD and how beneficial they can be to health and wellness, but these chemical compounds aren’t working alone. The euphoria you feel after consuming cannabis is a scientific art, and researchers are deeming it the ‘entourage effect.’ 

A woman holding trupura CBD Hemp Oil Tincture while exercising outdoors.

What is the entourage effect?

The entourage effect describes how all the chemical compounds of the cannabis plant work together to produce different effects and health benefits. Researchers now believe the therapeutic results we experience are thanks to a combination of cannabinoids, terpenes, and flavonoids working together in harmony. These reactions can also change based on what compounds may or may not be present in a product.

The Entourage Effect horizontal infographic illustration about cannabis as herbal alternative medicine and chemical therapy, healthcare and medical science vector.

Scientific studies on the entourage effect

Decades of prohibition, stigma, and sensational propaganda have left cannabis research studies few and far between. Most of the information anyone has ever shared about the physical and mental benefits of cannabis has been considered anecdotal. Thankfully, science is finally playing catch-up on understanding how cannabis fits into the mold of pharmacological medicine.

One prominent and detailed scientific study on the entourage effect was conducted by Dr. Ethan Russo called,“Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.” Through his research, Dr. Russo demonstrated the therapeutic benefits of cannabinoids and terpenes, and how these compounds synergistically work together.

Another study published in 2020 on the entourage effect showed how coupling terpenes with cannabinoids may be an important source for new medications intended to treat mood and anxiety disorders.

But how exactly do these other compounds interact with one another?

Doctor holding test tube with oil sample for hemp analysis, closeup


Cannabinoids are chemical compounds that provide relief for a long list of symptoms such as anxiety, pain, inflammation, nausea, and sleeping problems. As of now, scientists have identified at least 113 cannabinoids that exist alongside THC and CBD. 

What makes cannabinoids so remarkable is that they imitate compounds our bodies naturally produce through the endocannabinoid system. 

A quick recap: the endocannabinoid system (ECS) is made up of endocannabinoids, enzymes, and receptors that regulate our biological functions like sleep, appetite, pain sensory, memory, and so much more. Scientists don’t have all the answers to how exactly the ECS functions entirely. However, cannabis research offers a strong insight into how the plant’s chemical compounds react with the ECS when consumed.

How Does CBD Work In the Body horizontal infographic illustration about cannabis as herbal alternative medicine and chemical therapy, healthcare and medical science vector.  Demonstrates the entourage effect.


Terpenes are the aromatic compounds that give cannabis strains (and other plants, flowers, and fruits) their distinctive smells and flavors. They’re also responsible for amplifying the effects produced by individual cannabinoids. For example, some studies have found limonene and linalool may enhance the soothing, anti-anxiety effects offered from CBD. 

Nearly 200 terpenes have been identified with the five most common being:

  • Myrcene
  • Pinene
  • Limonene
  • Terpinolene 
  • Caryophyllene


Flavonoids make up roughly 10% of the compounds in the cannabis plant. And though flavonoids are found throughout nature, the ones unique only to cannabis are known as cannaflavins. The truth is, cannabis flavonoids deserve far more recognition than they get in the science world. 

Researchers have primarily paid attention to studying the effects of cannabinoids and terpenes. However, early research suggests that some cannabis flavonoids, more specifically Cannflavin A and Cannflavin B, may be 30 times more effective than aspirin at reducing inflammation! Other preliminary studies indicate flavonoids offer medical benefits but understanding how cannaflavins enhance the entourage effect still requires much more research.

A CBD tincture dropper close-up, dripping hemp oil into a bottle

Full-Spectrum, Broad-Spectrum, or Isolates: Which works better?

Cannabis flower, as is, already offers loads of terpenes and cannabinoids. But when these compounds are extracted and refined for CBD-infused products, you can experience an even better entourage effect!

Some people prefer vaping and/or ingesting cannabis extracts and oils because it’s an easy, smoke-free option. Plus, you still get the desired effect with a much smaller dosage. 

So how can you tell which CBD product will be the most beneficial? What you’ll want to look at the packaging to determine if it’s a full-spectrum, broad-spectrum, or isolate cannabis product. But what does this all mean? Here’s a quick summary:

  • Full-spectrum cannabis extracts offer a strong concentration of cannabinoids, terpenes, and flavonoids with less than .03% THC. 
  • Broad-spectrum CBD has been refined to contain everything but THC. This also describes CBD isolate products created with additional terpenes, flavonoids, and other minor cannabinoids.
  • Isolates contain a single compound only, normally THC or CBD. Isolated products can be perfect for canna-curious patients who don’t want to ingest cannabis compounds they’re unfamiliar with. 
A woman climber pulling a piece of trupura CBD Green Apple Gummies out of a jar.  Full-spectrum formulas offer consumers the entourage effect.

Experience the entourage effect for yourself with trupura CBD products!

Our store has full-spectrum and broad-spectrum CBD edibles, tinctures, soft gels, and topicals. You can either shop online or use our store locator to see which of our affiliates carries trupura CBD closest to you!

We never want our consumers to feel like their needs aren’t being treated properly, so sourcing high-quality hemp plants is critical to making our trupura CBD products. It’s the only way to capture all those cannabinoids, terpenes, and flavonoids into one perfect package!

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